Without a Trace (1983)

This film, centering on a child's abduction, casts Kate Nelligan as the distraught mother who lashes out at the police (in the person of a relentless detective played by Judd Hirsch), who treat her and her husband as suspects, even as she hounds them to find her child and drives away her husband (David Dukes) and friends (including Stockard Channing) with her intensity and single-mindedness.