The Powerpuff Girls (1998)

The straight-laced Prof. Utonium's attempt to create perfect little girls accidentally includes "Chemical X", resulting in take-charge red-head Blossom, blonde sweety-pie Bubbles and ready-to-fight brunette Buttercup. These flying, super-strong, karate-chopping girls with the occasional heat vision race into action to save the city of Townsville (and, we're told, the world) from all sorts of crimes and creatures.